comparing intramuscular progesterone, vaginal progesterone and 17 a-hydroxyprogestrone caproate in ivf and icsi cycle

نویسندگان

ashraf moini

fatemeh zafarani

bita eslami

maria sadeghi

چکیده

background: supplementation of luteal phase with progesterone is prescribed for women undergoing routine ivf treatment. objective: the objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates. materials and methods: a prospective randomized study was performed at royan institute between march 2008 and march 2009 in women under 40 years old, who use gnrh analog down-regulation. one hundred eighty six patients in three groups were received progesterone in oil (100 mg, im daily), intravaginal progesterone (400 mg, twice daily) and 17-? hydroxyprogestrone caproate (375mg, every three days), respectively. results: final statistical analysis after withdrawal of some patients was performed in 50, 50 and 53 patients in group 1, 2 and 3 respectively. no differences between the groups were found in baseline characteristics. no statistical significance different was discovered for biochemical, clinical and ongoing pregnancies. although the abortion rate was statistically higher in group 1 (p=0.025) the live birth rate was not statistically significant between the three groups. conclusion: the effects of three types of progesterone were similar on pregnancies rate. we suggest the use of intravaginal progesterone during the luteal phase in patients undergoing an ivf-et program because of the low numbers of abortions, and high ongoing pregnancy rates

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparing intramuscular progesterone, vaginal progesterone and 17 -hydroxyprogestrone caproate in IVF and ICSI cycle

BACKGROUND Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment. OBJECTIVE The objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates. MATERIALS AND METHODS A prospective randomized study was performed at Royan Institute bet...

متن کامل

Vaginal micronized progesterone capsule versus vaginal progesterone gel for lutheal support in normoresponder IVF/ICSI-ET cycles

OBJECTIVE To compare the outcomes of luteal phase support by micronized progesteron vaginal capsule 600mg/day and progesterone vaginal gel 180mg/day in the normoresponder IVF/ICSI-ET cycles of the patients down-regulated via GnRH agonist long protocol or fixed antagonist protocol below 40 years of age. METHODS A total of 463 normoresponder cycles between January 2013 and December 2013 were re...

متن کامل

Comparison of intravaginal progesterone gel and intramuscular 17-α-hydroxyprogesterone caproate in luteal phase support

The main objective of this study was to compare the pregnancy rates of intramuscular (IM) 17-α-hydroxyprogesterone caproate (17-HPC) and intravaginal (IV) progesterone gel administration in in vitro fertilization-embryo transfer (IVF-ET) cycles. The IM 17-HPC and IV progesterone groups included 632 (66.4%) and 320 (33.6%) women undergoing the first cycles of IVF-ET treatment, respectively. Mult...

متن کامل

Luteal phase bleeding after IVF cycles: comparison between progesterone vaginal gel and intramuscular progesterone and correlation with pregnancy outcomes

BACKGROUND To compare luteal phase bleeding and pregnancy outcomes in normogonadotropic patients receiving progesterone vaginal gel (PVG) or intramuscular progesterone (IMP) injections. METHODS In this retrospective cohort study, data from 270 patients (292 cycles) undergoing day-3 fresh embryo transfer were analyzed. PVG, 90 mg daily (170 cycles) or IMP, 50 mg daily (122 cycles) began at egg...

متن کامل

Progesterone bioavailability with a progesterone-releasing silicone vaginal ring in IVF candidates.

A vaginal ring made of silicone polymers and barium sulfate, and containing 1 g of pure micronized progesterone, was developed for luteal supplementation in women undergoing cycles of in vitro fertilization (IVF). The ring, modeled on the Estring, was designed as a means of providing continuous intravaginal delivery of progesterone. Bioavailability of progesterone in the blood was demonstrated ...

متن کامل

Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety.

Progestogens are the first drugs to demonstrate reproducibly a reduction in the rate of early preterm birth. The efficacy and safety of progestogens are related to individual pharmacologic properties of each drug within this class of medication and characteristics of the population that is treated. The synthetic 17-hydroxyprogesterone caproate and natural progesterone have been studied with the...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of reproductive biomedicine

جلد ۹، شماره ۲، صفحات ۱۱۹-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023